{"id":25,"date":"2023-04-04T13:01:35","date_gmt":"2023-04-04T13:01:35","guid":{"rendered":"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/?page_id=25"},"modified":"2023-04-13T15:01:11","modified_gmt":"2023-04-13T15:01:11","slug":"expected-results","status":"publish","type":"page","link":"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/","title":{"rendered":"Expected results"},"content":{"rendered":"<!-- Preview block -->\n<img loading=\"lazy\" width=\"100%\" height=\"100%\" src=\"\"\/>\n\n<div class=\"block-banner \" data- style=\"background-image: url(https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/Banners-Research-2-1.png)\">\n    <div class=\"inner-container\">\n      <div class=\"text-box\">\n        <h2 class=\"title\">Research<\/h2>\n        <div class=\"text\">\n          <p>Expected results<\/p>\n\n        <\/div>\n      <\/div>\n    <\/div>\n<\/div>\n\n<style type=\"text\/css\">\n  [data-] {\n    background: ;\n    color: ;\n  }\n<\/style>\n\n\n\n\n<p>IL7R is a bona fide oncogene in the context of lymphoid development. However, despite the evidence suggesting that the pro-tumoral role of IL-7-IL-7R axis extends to non-hematopoietic cancers, there is still no formal evidence that IL7R is an oncogene in solid tumors. Our proposal will: <\/p>\n\n\n\n<p><strong><span style=\"color:#c17e5a\" class=\"has-inline-color\">i) <\/span><\/strong>establish whether IL7R is a broader oncogene than initially anticipated; <\/p>\n\n\n\n<p><strong><span style=\"color:#c17e5a\" class=\"has-inline-color\">ii)<\/span><span style=\"color:#00c6a5\" class=\"has-inline-color\"> <\/span><\/strong>characterize whether IL-7R is not only a biomarker, but also actually involved in the mechanisms, of resistance to PD-1 axis inhibition; <\/p>\n\n\n\n<p><strong><span style=\"color:#c17e5a\" class=\"has-inline-color\">iii)<\/span><\/strong> generate innovative tools to target IL-7R-expression tumor cells and concomitantly potentiate anti-tumor immune responses. The breadth of findings, unique cellular and in vivo models, and novel therapeutic tools with clinical potential that we will generate may extend beyond NCSLC and lung cancer in general, to any IL-7R-expressing tumor, including glioma or breast, bladder, prostate and colorectal cancer, amongst others (reviewed in [7]). If successful, our paradigm-shifting proposal will not only demonstrate that IL7R is an oncogene in solid tumors but also characterize the mechanisms by which a major anti-tumor immune gene is co-opted by cancer cells to benefit tumor progression and treatment resistance. Furthermore, we may ultimately impact clinical practice, introducing a novel biomarker of resistance to PD-1 axis blockade and generating tools to effectively improve treatment outcome in lung cancer and beyond.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" src=\"http:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/la-caixa-foundation-vertical-white-background.jpg\" alt=\"\" class=\"wp-image-168\" width=\"158\" height=\"75\" srcset=\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/la-caixa-foundation-vertical-white-background.jpg 630w, https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/la-caixa-foundation-vertical-white-background-300x143.jpg 300w\" sizes=\"(max-width: 158px) 100vw, 158px\" \/><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"<p>IL7R is a bona fide oncogene in the context of lymphoid development. However, despite the evidence suggesting that the pro-tumoral role of IL-7-IL-7R axis extends to non-hematopoietic cancers, there is still no formal evidence that IL7R is an oncogene in solid tumors. Our proposal will: i) establish whether IL7R is a broader oncogene than initially &hellip; <a href=\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/\">Continued<\/a><\/p>\n","protected":false},"author":13,"featured_media":0,"parent":19,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"views\/template-900.blade.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Expected results - IL7RLungC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Expected results - IL7RLungC\" \/>\n<meta property=\"og:description\" content=\"IL7R is a bona fide oncogene in the context of lymphoid development. However, despite the evidence suggesting that the pro-tumoral role of IL-7-IL-7R axis extends to non-hematopoietic cancers, there is still no formal evidence that IL7R is an oncogene in solid tumors. Our proposal will: i) establish whether IL7R is a broader oncogene than initially &hellip; Continued\" \/>\n<meta property=\"og:url\" content=\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/\" \/>\n<meta property=\"og:site_name\" content=\"IL7RLungC\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-13T15:01:11+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/la-caixa-foundation-vertical-white-background.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/en\/#website\",\"url\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/en\/\",\"name\":\"IL7RLungC\",\"description\":\"Mais um site Sites de iMM\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"http:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/la-caixa-foundation-vertical-white-background.jpg\",\"contentUrl\":\"http:\/\/il7rlungc.imm.medicina.ulisboa.pt\/wp-content\/uploads\/sites\/37\/2023\/04\/la-caixa-foundation-vertical-white-background.jpg\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/#webpage\",\"url\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/\",\"name\":\"Expected results - IL7RLungC\",\"isPartOf\":{\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/#primaryimage\"},\"datePublished\":\"2023-04-04T13:01:35+00:00\",\"dateModified\":\"2023-04-13T15:01:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\\u00edcio\",\"item\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Expected results\"}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Expected results - IL7RLungC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/il7rlungc.imm.medicina.ulisboa.pt\/research\/expected-results\/","og_locale":"en_US","og_type":"article","og_title":"Expected results - IL7RLungC","og_description":"IL7R is a bona fide oncogene in the context of lymphoid development. 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